Clinical remission rate and drug withdrawal status in articular juvenile idiopathic arthritis
Authors' conclusion
OJIA had the highest rate of clinical remission off medication (67%) versus others.
Study context
- Population
- Patients who developed articular juvenile idiopathic arthritis (JIA) by 2017 and were followed up (2013–2022)16 polyarticular JIA (PJIA), 33 oligoarticular JIA (OJIA)
- Participants
- 49 patients
- Exposure
- PJIA vs OJIA
- OJIAn = 33
- Outcome
- Clinical remission rate (Wallace criteria) and drug withdrawal status
Methodological detailsretrospective observational, Wallace criteria used as remission criteria
- Retrospective observational
- Wallace criteria used as remission criteria
Main finding
As reported in the abstract
Clinical remission off medication
OJIA
67%
Observational data: associations, not effects.
Further findings
- Flare within 2 years after csDMARD withdrawal — OJIA
- 30%
- Flare within 2 years after biological disease-modifying antirheumatic drug (bDMARD) withdrawal — OJIA
- 50%
- bDMARD introduction rate — Significantly higher in RF + PJIA
- p < 0.01
- Flare within 2 years after bDMARD withdrawal — Two cases each of RF - PJIA and OJIA discontinued bDMARDs
- 2
- Flare within 2 years after bDMARD withdrawal — OJIA cases with remission maintained after withdrawal of all drugs
- 1
- bDMARD introduction rate: RF + PJIA 86%
- Flare within 2 years after csDMARD withdrawal: RF + PJIA 50%
- Flare within 2 years after csDMARD withdrawal: RF - PJIA 25%
- Flare within 2 years after bDMARD withdrawal: RF - PJIA 100%
Original publication
Clinical remission rate and drug withdrawal status in articular juvenile idiopathic arthritis. Pediatr Rheumatol Online J. Published 24 February 2025. doi:10.
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