Exposure-response relationship of mycophenolic acid in pediatric lupus nephritis patients receiving multi-target therapy: An observational cohort study
Authors' conclusion
There is a significant correlation between MPA-AUC0-12h and treatment response in pediatric LN patients receiving multi-target therapy
Study context
- Population
- Pediatric lupus nephritis (LN) patients receiving multi-target therapy (mycophenolate mofetil (MMF), tacrolimus and prednisone)
- Participants
- 48 patients
- Outcome
- MPA-AUC0-12h effectiveness threshold for renal remission
- Follow-up
- 6 months
Methodological detailslimited sampling strategy, ROC analysis, Kaplan-Meier analysis
- Limited sampling strategy
- ROC analysis
- Kaplan-Meier analysis
Main finding
As reported in the abstract
MPA-AUC0-12h threshold for renal remission
Threshold
25.24 μg·h·mL⁻¹
AUC (P = 0.0002)
0.83
Observational data: associations, not effects.
Further findings
MPA-AUC threshold for renal remission · 12 months
- Threshold
- 23.52 μg·h·mL⁻¹
- AUC (P < 0.0001)
- 0.89
MPA-AUC0-12h threshold for inactive systemic lupus erythematosus (SLE) · 6 months
- Threshold
- 31.16 μg·h·mL⁻¹
- AUC (P = 0.0004)
- 0.80
MPA-AUC0-12h threshold for inactive SLE · 12 months
- Threshold
- 28.87 μg·h·mL⁻¹
- AUC (P = 0.0012)
- 0.82
Time to renal response or inactive SLE
- Patients reaching target MPA-AUC0-12h thresholds achieved renal response or inactive SLE more rapidly
Original publication
Exposure-response relationship of mycophenolic acid in pediatric lupus nephritis patients receiving multi-target therapy: An observational cohort study. Semin Arthritis Rheum. Published 22 February 2025. doi:10.
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