Serum and salivary inflammatory biomarkers in juvenile idiopathic arthritis—an explorative cross-sectional study
Authors' conclusion
In this explorative study, the serum and salivary biomarker patterns differed markedly, suggesting that saliva may not be a suitable substitute for serum when assessing systemic inflammation in JIA.
Study context
- Population
- Norwegian children and adolescents with non-systemic juvenile idiopathic arthritis (JIA) and matched controls from the NorJIA Study; predominantly females, median age 14 years
- Participants
- 42 vs 30
- Exposure
- Non-systemic JIA vs matched controls; active vs inactive JIA
- JIAn = 42
- Controlsn = 30reference
- Outcome
- Patterns of 92 inflammation-related biomarkers in serum and saliva (multiplex assay)
Methodological detailsexplorative, matched controls, subset of the NorJIA Study
- Explorative
- Matched controls
- Subset of the NorJIA Study
Main finding
As reported in the abstract
Biomarkers detected in serum
87
Biomarkers detected in saliva
73
Biomarkers detected in both biofluids
71
Observational data: associations, not effects.
Original publication
Serum and salivary inflammatory biomarkers in juvenile idiopathic arthritis—an explorative cross-sectional study. Pediatr Rheumatol Online J. Published 9 March 2024. doi:10.
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