Pediatric rheumatology

Bone health in juvenile idiopathic arthritis compared with controls based on a Norwegian observational study

RMD OpenPublished Prospective cohort study

Authors' conclusion

BMD Z-scores in JIA were similar to controls and positively associated with physical activity.

Study context

Population
Norwegian children with juvenile idiopathic arthritis (JIA) and age- and sex-matched controls (NorJIA study); median age 14.7 years at visit 2matched controls
Participants
205 vs 125
Exposure
JIA vs age- and sex-matched controls
  • JIAn = 205
  • Controlsn = 125reference
Outcome
BMD Z-score L1-L4 measured by DXA, adjusted for bone age
Follow-up
Visit 2
Methodological detailsmulticentre, age-matched and sex-matched controls
  • Multicentre
  • Age-matched and sex-matched controls

Main finding

As reported in the abstract

Mean BMD Z-score L1-L4

JIA

0.0

mean · 95% CI −0.1–0.1

Controls

0.1

mean · 95% CI −0.1–0.3

Observational data: associations, not effects.

Further findings

Mean BMD Z-score L1-L4 by physical activity level in JIA
Mean
Low activity (JIA)
−0.3(95% CI −0.6–0.0)
High activity (JIA)
0.2(95% CI 0.0–0.4)
Robust association between physical activity levels and BMD; similar trend in controls

Physical activity

Children with JIA were as physically active as controls

Original publication

Bone health in juvenile idiopathic arthritis compared with controls based on a Norwegian observational study. RMD Open. Published 19 June 2025. doi:10.1136/rmdopen-2025-005605

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