Disease activity trajectories from childhood to adulthood in the population-based Nordic juvenile idiopathic arthritis cohort
Authors' conclusion
In our study the PaGA was the most important driver of disease activity into adulthood assessed by cJADAS10.
Study context
- Population
- Patients with onset of juvenile idiopathic arthritis (JIA) in 1997–2000, followed for 18 years in the population-based Nordic JIA cohort
- Participants
- 427 patients
- Outcome
- Long-term disease activity trajectories from childhood to adulthood by clinical Juvenile Arthritis Disease Activity Score (cJADAS10)
- Follow-up
- 18-year follow-up
Methodological detailspopulation-based, discrete mixture model for longitudinal clustering, hierarchical clustering and correlation analysis
- Population-based
- Discrete mixture model for longitudinal clustering
- Hierarchical clustering and correlation analysis
Main finding
As reported in the abstract
Disease activity trajectories (cJADAS10 components)
- Four disease activity trajectories identified
- 4
- Increase in PaGA significantly higher than increases in PhGA and active joint count
- p<0.0001
Observational data: associations, not effects.
Further findings
All patients with active disease in the total cohort
- Similar pattern (PaGA increase predominant)
Patient-reported outcomes by PaGA
- Patients with higher PaGA scores had unfavourable scores on several other patient-reported outcomes
Original publication
Disease activity trajectories from childhood to adulthood in the population-based Nordic juvenile idiopathic arthritis cohort. RMD Open. Published 8 March 2024. doi:10.
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