Gene association analysis to determine the causal relationship between immune cells and juvenile idiopathic arthritis
Authors' conclusion
Our study assessed the causal effect of immune cells on JIA from a genetic perspective.
Study context
- Population
- 731 immune cell phenotypes (median fluorescence intensity (MFI), relative cellular (RC), absolute cellular (AC), morphological parameters (MP)) and juvenile idiopathic arthritis (JIA)
- Comparison
- Genetically predicted immune cell phenotypes and JIA
- Outcome
- Causal relationship between immune phenotypes and the onset of JIA
Methodological detailsbidirectional, sensitivity analysis
- Bidirectional
- Sensitivity analysis
Main finding
As reported in the abstract
Immune phenotypes causally associated with JIA
- CD3 on CM CD8br causally associated with JIA (significance level 0.05), 95% CI
- 0.630 ≈0.847
- CD3 on CM CD8br, P
- P = 3.33 × 10-5
- CD3 on CM CD8br, PFDR
- PFDR = 0.024
- HLA DR on CD14+ CD16- monocyte causally associated with JIA (significance level 0.20), 95% CI
- 0.633 ≈0.884
- HLA DR on CD14+ CD16- monocyte, P
- P = 6.83 × 10-4
- HLA DR on CD14+ CD16- monocyte, PFDR
- PFDR = 0.16
- HLA DR on CD14+ monocyte causally associated with JIA (significance level 0.20), 95% CI
- 0.627 ≈0.882
- HLA DR on CD14+ monocyte, P
- P = 6.9 × 10-4
- HLA DR on CD14+ monocyte, PFDR
- PFDR = 0.16
Original publication
Gene association analysis to determine the causal relationship between immune cells and juvenile idiopathic arthritis. Pediatr Rheumatol Online J. Published 8 March 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →