Vitamin D Levels and Risk of Juvenile Idiopathic Arthritis: A Mendelian Randomization Study
Authors' conclusion
Given the lack of a causal relationship between 25-(OH)D levels and JIA, population level vitamin D supplementation is unlikely to reduce JIA incidence.
Study context
- Population
- European populations: GWAS of 25-(OH)D levels and 2 juvenile idiopathic arthritis (JIA) genetic studiesGWAS n 443,734
- Comparison
- Genetically predicted 25-D levels and JIA incidence
- Outcome
- Causal effect of 25-(OH)D on JIA incidence
Methodological details2-sample Mendelian randomization (MR), summary level data, multiple MR methods and sensitivity analyses
- 2-sample MR
- Summary level data
- Multiple MR methods and sensitivity analyses
Main finding
As reported in the abstract
JIA incidence per SD increase in standardized natural-log transformed 25-(OH)D
OR (95% CI 0.76, 1.33) per SD increase in 25-(OH)D
1.00
Further findings
Reverse direction: genetically predicted JIA on 25-(OH)D levels
- SD change in standardized natural-log transformed 25-(OH)D per doubling odds in JIA
- −0.002 (95% CI −0.006, 0.002)
Original publication
Vitamin D Levels and Risk of Juvenile Idiopathic Arthritis: A Mendelian Randomization Study. Arthritis Care Res (Hoboken). Published 26 November 2022. doi:10.
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