Genetic Association of Juvenile Idiopathic Arthritis With Adult Rheumatic Disease
Authors' conclusion
In this genetic association study, there was significant genetic overlap between JIA and adult rheumatic diseases.
Study context
- Population
- Patients from 4 disease genome-wide association study (GWAS) cohorts, 2013 to 2024 (juvenile idiopathic arthritis (JIA), RA, SLE, SSc); JIA from the US, Australia, Norway and UK; others from US and Western European countries
- Participants
- 33,207 patients4 cohorts
- Comparison
- JIA vs adult rheumatic diseases
- JIAn = 4,550
- RAn = 143 61
- SLEn = 5,201
- SScn = 9,095
- Outcome
- Genetic correlations and shared genomic loci between JIA and adult rheumatic diseases
Methodological detailsGWAS cohorts, genetic correlation analyses, cross-trait meta-analysis, Mendelian randomization, All analyses conducted between September 2023 and April 2024
- GWAS cohorts
- Genetic correlation analyses
- Cross-trait meta-analysis
- Mendelian randomization
- All analyses conducted between September 2023 and April 2024
Pooled result
As reported in the abstract
Regions harboring signals associated with multiple diseases
84
Loci associated with JIA and adult diseases (cross-trait analyses), plus novel disease loci
20
Further pooled results
Mendelian randomization: proteins significantly associated with rheumatic disorders
- Proteins significantly associated with rheumatic disorders
- 11
- Shared, organ-specific and disease-specific critical cell types highlighted
Original publication
Genetic Association of Juvenile Idiopathic Arthritis With Adult Rheumatic Disease. JAMA Netw Open. Published 2 December 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →