Causal relationship between serum metabolites and juvenile idiopathic arthritis: a mendelian randomization study
Authors' conclusion
Five serum metabolites, including kynurenine and 3-dehydrocarnitine, may be causally associated with JIA.
Study context
- Population
- Genetic variation data and genome-wide association study summary data on Juvenile Idiopathic Arthritis (JIA) and 486 serum metabolites486 serum metabolites
- Comparison
- Genetically predicted levels of 486 serum metabolites and JIA
- Outcome
- Metabolic pathways associated with JIA, identified by KEGG pathway enrichment analysis
Methodological detailstwo-sample, univariate Mendelian randomization (MR), inverse variance weighted, MR-Egger, sensitivity analyses
- Two-sample
- Univariate MR
- Inverse variance weighted
- MR-Egger
- Sensitivity analyses
Main finding
As reported in the abstract
JIA (causal association with serum metabolites)
Odds ratio (95% CI)P value
Kynurenine (risk factor)
16.39(2.07–129.63)
P = 5.11 × 10- 6Linolenate (risk factor)
16.48(1.32–206.22)
P = 0.0303-dehydrocarnitine (protective factor)
0.32(0.14–0.72)
P = 0.007Levulinate (4-oxovalerate) (protective factor)
0.40(0.20–0.80)
P = 0.010X-14,208 (phenylalanylserine) (protective factor)
0.68(0.51–0.92)
P = 0.010- Five metabolites significantly causally associated with JIA
- 5
Further findings
Metabolic pathways (KEGG enrichment)
- Metabolic pathways potentially associated with onset and progression of JIA, incl. α-linolenic acid metabolism and pantothenate and CoA biosynthesis
- 7
Original publication
Causal relationship between serum metabolites and juvenile idiopathic arthritis: a mendelian randomization study. Pediatr Rheumatol Online J. Published 9 May 2024. doi:10.
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