Adherence to low-dose methotrexate in children with juvenile idiopathic arthritis using a sensitive methotrexate assay
Authors' conclusion
Quantification of MTX in plasma is a feasible and objective method to assess adherence in patients using low-dose weekly MTX.
Study context
- Population
- Children with JIA on low-dose weekly methotrexate (MTX)
- Participants
- 43 children
- Outcome
- MTX adherence assessed by quantification of MTX concentrations in plasma
Methodological detailsultrasensitive LC-MS/MS assay of MTX and 7-hydroxy-MTX in plasma, plasma concentrations compared with adherence limits
- Ultrasensitive LC-MS/MS assay of MTX and 7-hydroxy-MTX in plasma
- Plasma concentrations compared with adherence limits
Main finding
As reported in the abstract
Adherence to MTX (plasma MTX concentration)
Adherence shortly after MTX initiation
88%
Adherence after one year of treatment
77%
Observational data: associations, not effects.
Further findings
Risk of non-adherence in teenagers
- Teenagers more at risk for non-adherence
- P = 0.002
Association of MTX adherence with self-reported adherence issues
- No association found (Fisher's Exact)
- P = 1.00
Association of MTX adherence with concomitant biological treatment
- No association found (Fisher's Exact)
- P = 0.27
Original publication
Adherence to low-dose methotrexate in children with juvenile idiopathic arthritis using a sensitive methotrexate assay. Pediatr Rheumatol Online J. Published 7 May 2024. doi:10.
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