Disease activity trajectories in juvenile dermatomyositis from childhood to adulthood
Authors' conclusion
High early disease activity, and treatment resistance in the first few months, predict a more chronic longitudinal course of JDM.
Study context
- Population
- Patients with IIM, largely JDM, followed throughout childhood and into adulthood (64% females; median age at diagnosis 7.7 years)4,725 visits (1471 patient-years)
- Participants
- 172 patients
- Exposure
- Class 1 vs Class 2 vs Class 3
- Outcome
- Latent classes of longitudinal disease activity trajectory (modified DAS, DASm) and baseline factors predicting class membership
Methodological detailslongitudinal, inception cohort, latent class trajectory analysis
- Longitudinal
- Inception cohort
- Latent class trajectory analysis
Main finding
As reported in the abstract
Latent classes of longitudinal disease activity (DASm), model with baseline DASm and change from baseline to 6 months as predictors
Class 1
10%
Class 2
34%
Class 3
56%
Observational data: associations, not effects.
Original publication
Disease activity trajectories in juvenile dermatomyositis from childhood to adulthood. Rheumatology (Oxford). Published 12 January 2024. doi:10.
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