Type I interferon endotypes drive divergent clinical trajectories in childhood-onset SLE uncovered through a novel systems immunology approach
Authors' conclusion
Multilevel IFN profiling revealed an important biomarker of IFN-high patients for potential use in clinical practice, immune lineage-specific responses, and clinically meaningful endotypes, supporting systems immunology approaches and biomarker-guided personalised treatment strategies.
Study context
- Population
- Young females with childhood-onset SLE and matched controls
- Comparison
- cSLE vs matched controls
- Outcome
- IFN-I signalling profiles in cSLE
Methodological detailsmultiomic, matched controls, longitudinal trajectory analysis, independent validation cohorts
- Multiomic
- Matched controls
- Longitudinal trajectory analysis
- Independent validation cohorts
Main finding
As reported in the abstract
IFN-high patients
65%
IFN-low patients
35%
IFN-driven endotypes with unique immune signatures and clinical phenotypes
6
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Type I interferon endotypes drive divergent clinical trajectories in childhood-onset SLE uncovered through a novel systems immunology approach. Ann Rheum Dis. Published 14 January 2026. doi:10.
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