Nationwide analysis of childhood-onset systemic lupus erythematosus mortality in Mexico, 2000–2023
Main finding · cSLE ASMR per 100,000 by sexResult — go to the resultIncidence rate ratio 0.24 95% CI 0.19–0.29Authors' conclusion
cSLE mortality in Mexico has remained stable over time, with a marked female predominance.
Study context
- Population
- Children aged 1–14 years whose deaths were attributed to cSLE, Mexico, 2000–2023 (INEGI national death registry)cSLE deaths among 280,334 child deaths
- Participants
- 637 children
- Exposure
- Male vs female; by region
- Outcome
- Trends in ASMRs (per 100,000 population) from cSLE, stratified by sex and region
Methodological detailsretrospective, nationwide death registry, Poisson regression with log link and population offset
- Retrospective
- Nationwide death registry
- Poisson regression with log link and population offset
Main finding
cSLE ASMR per 100,000 by sex · 2000–2023
Incidence rate ratio
0.24
95% CI 0.19–0.29
P < 0.001
By group
Boysvs Girls
IRR 0.24 (95% CI 0.19–0.29); P < 0.001
As reported in the abstract
Observational data: associations, not effects.
Further findings
- Age-standardized mortality rates (ASMRs) similar across regions (range per 100,000)
- 0.08-0.09
- Central and Midwest regions concentrated over 60% of total deaths
- No statistically significant regional differences
Original publication
Nationwide analysis of childhood-onset systemic lupus erythematosus mortality in Mexico, 2000–2023. Lupus. Published 24 April 2026. doi:10.
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