Is time a healer? How quality of life changes over time reported by parents of children and young people with juvenile idiopathic arthritis
Authors' conclusion
Children and young people with JIA have low HRQoL across domains compared with the reference population. This improves within 3 years of diagnosis, with the greatest improvement within the first year.
Study context
- Population
- Children and young people with JIA recruited to the Childhood Arthritis Prospective Study (CAPS), >5 years of age at diagnosismedian age 9.6 years (IQR 7.2–12.2)
- Participants
- 182 children
- Exposure
- Change in health-related quality of life (HRQoL) over 3 years from diagnosis; by gender and age at onset
- Outcome
- Change in HRQoL (proxy-reported CHQ) over 3 years following diagnosis
- Follow-up
- 3 years
Methodological detailslongitudinal, proxy-reported (parent/guardian) Child Health Questionnaire (CHQ), comparison with a US reference population
- Longitudinal
- Proxy-reported (parent/guardian) CHQ
- Comparison with a US reference population
Main finding
As reported in the abstract
HRQoL domains (CHQ) over follow-up
- All HRQoL domains significantly improved over the 3 year follow-up, except general health perceptions
- Physical health domains showed greater improvement than psychosocial domains; psychosocial scores generally higher than physical scores throughout
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| HRQoL by gender (females vs males) · 1 yearFemales vs Males · physical functioning; females significantly worse | P = 0.03 |
| HRQoL by gender (females vs males) · 1 yearFemales vs Males · bodily pain; females significantly worse | P = 0.03 |
| HRQoL by gender (females vs males) · 1 yearFemales vs Males · mental health; females significantly worse | P = 0.00 |
| HRQoL by gender (females vs males) · 1 yearFemales vs Males · social-emotional; females significantly worse | P = 0.02 |
| HRQoL by gender (females vs males) · 1 yearFemales vs Males · social-physical; females significantly worse | P < 0.001 |
HRQoL by gender (females vs males) · 1 year
- Similar at diagnosis
- Differences largely remained at 3 years
HRQoL by age at onset
- Age at onset was not significantly associated with HRQoL
Original publication
Is time a healer? How quality of life changes over time reported by parents of children and young people with juvenile idiopathic arthritis. Rheumatology (Oxford). Published 24 May 2022. doi:10.
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