Serum levels and significance of soluble B-cell maturation antigen in childhood-onset systemic lupus erythematosus with renal involvement
Authors' conclusion
In cSLE patients with renal involvement, serum sBCMA levels correlated significantly with disease activity, immunological, and hematological parameters, but not with renal parameters.
Study context
- Population
- Children with childhood-onset SLE with renal involvement (84 females, 32 males; median age 11.6 years), Department of Pediatric Nephrology and Rheumatology, First Affiliated Hospital, Sun Yat-sen University116 cSLE and 31 healthy controls (HCs)
- Participants
- 116 vs 31
- Exposure
- cSLE with renal involvement vs healthy controls
- cSLEn = 116
- HCsn = 31reference
- Outcome
- Serum sBCMA levels and their association with clinical characteristics
Methodological detailsretrospective analysis of clinical and laboratory information, single-centre, enzyme-linked immunosorbent assay (ELISA)
- Retrospective analysis of clinical and laboratory information
- Single-centre
- ELISA
Main finding
As reported in the abstract
Serum sBCMA levels
- Serum soluble B-cell maturation antigen (sBCMA) significantly increased in primary cSLE vs treated cSLE and HCs
- No significant difference between treated cSLE and HCs
- Higher sBCMA with high disease activity vs no or mild to moderate activity
- Positive correlation with SLEDAI-2K, ANA titers, anti-dsDNA titers, ESR and IgG levels
- Negative correlation with white blood cell count, hemoglobin, platelet count, C3 and C4
- No correlation with renal parameters
Observational data: associations, not effects.
Further findings
- Serum sBCMA decreased as disease ameliorated after treatment
- 11 cases with follow-up examinations
Original publication
Serum levels and significance of soluble B-cell maturation antigen in childhood-onset systemic lupus erythematosus with renal involvement. Lupus. Published 13 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →