Echocardiographic assessment of pediatric lupus nephritis and its correlation with disease activity in a tertiary care hospital
Authors' conclusion
Cardiac abnormalities are prevalent in pediatric LN and valvular dysfunction particularly tricuspid regurgitation being the most common followed by pericardial effusion and pulmonary hypertension. These abnormalities correlate with higher disease activity and lower C3 levels
Study context
- Population
- Children with Lupus Nephritis (LN) fulfilling Systemic Lupus International Collaborating Clinics (SLICC) 2012 criteria for systemic lupus erythematosus (SLE) with renal involvement, Department of Pediatric Nephrology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh, January 2017 to July 2023male-to-female ratio 1:3
- Participants
- 50 children
- Outcome
- Cardiac abnormalities on color doppler echocardiography
Methodological detailsanalytical, single-centre
- Analytical
- Single-centre
Main finding
As reported in the abstract
Cardiac abnormalities on echocardiography
Any cardiac abnormality
20 patients
40%
Tricuspid regurgitation (most frequent)
38%
Pericardial effusion
28%
Pulmonary hypertension
24%
Observational data: associations, not effects.
Further findings
Association of abnormal echocardiographic (ECHO) findings with disease activity and C3
- Abnormal ECHO findings significantly associated with higher systemic lupus erythematosus disease activity index (SLEDAI) scores and lower C3 levels
Age at presentation
- Mean age at presentation, years (± SD)
- 12.4 ± 2.79
Original publication
Echocardiographic assessment of pediatric lupus nephritis and its correlation with disease activity in a tertiary care hospital. Lupus. Published 9 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →