Haematological and other manifestions in the presence of antiphospholipid antibodies in a multicentric paediatric cohort
Authors' conclusion
Non-criteria manifestations and among them haematological disorders, are the most frequent events in the presence of aPLs and/or LA in our paediatric cohort. Children with SLE, LA and/or IgG aβ2GPI positivity showed a higher risk of haematological manifestations.
Study context
- Population
- Children under the age of 18 years with aPLs
- Participants
- 134 participants
- Outcome
- Variables associated with haematological manifestations in the presence of aPLs
Methodological detailsmulticentric
- Multicentric
Main finding
As reported in the abstract
Independent risk factors for haematological manifestations (stepwise regression)
- IgG aβ2GPI positivity: OR 2.91, 95% CI (1.26-6.74)
- p=0.013
- SLE: OR 2.67, 95% CI (1.13-6.3)
- p=0.026
- LA positivity: OR 2.53, 95% CI (1.08-5.94)
- p=0.033
Observational data: associations, not effects.
Further findings
Manifestations in the cohort
- At least one thrombotic event
- 12.2%
- At least one non-criterion manifestation
- 67%
- Of them, no thrombotic event (TE)
- 90%
- Haematological
- 42%
- Neurological
- 19.8%
- Cutaneous
- 17.6%
- Cardiac
- 16.8%
- Renal
- 1.5%
aPL positivity in children with haematological disorders
- LA
- 67.3%
- aβ2GPI
- 65.6%
- aCL
- 60%
- Single
- 45.5%
- Double
- 23.6%
- Triple
- 30.9%
Univariate: higher frequency of haematological manifestations with IgM aCL+, IgM aβ2GPI+, triple positivity and SLE
- Significantly higher frequency
- P < 0.05
Original publication
Haematological and other manifestions in the presence of antiphospholipid antibodies in a multicentric paediatric cohort. Clin Exp Rheumatol. Published 9 March 2023. doi:10.
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