Data from a multicentric international study unveils a neglected association between chronic non-bacterial osteomyelitis and inflammatory bowel diseases
Authors' conclusion
The persistence of inflammation and the presence of microcytic anaemia were associated with the development of an IBD.
Study context
- Population
- Paediatric patients with chronic non-bacterial osteomyelitis followed at Istituto Gaslini, Genova, and Hacettepe Hospital, Ankara
- Participants
- 19 vs 57
- Exposure
- CNO associated with IBD vs CNO without gastrointestinal disease
- C-IBDn = 19
- CNOn = 57reference
- Outcome
- Clinical and laboratory features, C-IBD vs CNO
Methodological detailsmulticentre, international, registry-based (Eurofever Registry), with literature review, Literature review on paediatric C-IBD also performed
- Multicentre
- International
- Registry-based (Eurofever Registry)
- With literature review
- Literature review on paediatric C-IBD also performed
Main finding
As reported in the abstract
- Spinal involvement more frequent in CNO (p<0.05)
- Sacroiliac involvement more frequent in C-IBD (p<0.005)
Observational data: associations, not effects.
Further findings
Low-grade fever
P < 0.05
Microcytic anaemia
P = 0.0005
Positive fecal calprotectin
P < 0.0001
| Outcome | C-IBD | CNO | P value |
|---|---|---|---|
| CRP elevation | All | 45% | P < 0.0001 |
- CRP persistently elevated until IBD treatment started (C-IBD)
- 68.4%
Disease onset in C-IBD
- Osteoarticular symptoms
- 73.6%
- Gastrointestinal symptoms
- 10.5%
- Simultaneous
- 15.8%
Original publication
Data from a multicentric international study unveils a neglected association between chronic non-bacterial osteomyelitis and inflammatory bowel diseases. Clin Exp Rheumatol. Published 14 March 2025. doi:10.
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