Clinical characteristics and outcomes of paediatric chronic non-bacterial osteomyelitis: a retrospective cohort study with focus on zoledronic acid
Authors' conclusion
Zoledronic acid was associated with high clinical and radiological response rates and was well tolerated.
Study context
- Population
- Children diagnosed with chronic non-bacterial osteomyelitis 2014–2024, Royal Children's Hospital, Melbourne (mean age 10.3 years; 70% female)median follow-up 3.7 years
- Participants
- 57 children
- Outcome
- Effectiveness and tolerability of ZA (clinical and MRI response, adverse effects)
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Significant clinical improvement with ZA
Zoledronic acid (ZA)
77%
Observational data: associations, not effects.
Further findings
| Outcome | Values |
|---|---|
| Significant radiological improvement on whole-body MRI (10 patients with pre- and post-ZA MRI) | ZA 80% |
| Later required TNFi after ZA | ZA 3 events |
Multifocal disease (whole cohort)
- Multifocal disease
- 86%
- Underwent biopsy
- 63%
Safety
| Outcome | Values |
|---|---|
| Mild, transient flu-like symptoms | ZA 54% |
| Serious adverse events | ZA 0 events |
Original publication
Clinical characteristics and outcomes of paediatric chronic non-bacterial osteomyelitis: a retrospective cohort study with focus on zoledronic acid. Rheumatology (Oxford). Published 19 August 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →