Lupus & antiphospholipid syndrome
Urinary CD163 is a marker of active kidney disease in childhood-onset lupus nephritis
Authors' conclusion
Urine CD163 emerges as a promising marker for identifying cSLE patients with active kidney disease.
Study context
- Population
- Pediatric patients fulfilling four or more ACR criteria for SLE (childhood-onset SLE) and healthy controls60 cSLE patients + 20 controls
- Comparison
- Urine CD163 in active LN vs inactive SLE and healthy controls
- Healthy controlsn = 20reference
- Outcome
- Utility of urine CD163 (ELISA) for detecting disease activity in cSLE
Methodological detailsconsecutive recruitment
- Consecutive recruitment
Performance
As reported in the abstract
Urine CD163, active LN vs inactive SLE and healthy controls
ROC AUC range
0.93 to 0.96
Further findings
Correlations of urine CD163
- Significantly correlated with SLEDAI, renal SLEDAI, urinary protein excretion and C3 levels
- Associated with high renal pathology activity and chronicity index; strong correlation with interstitial inflammation and interstitial fibrosis on concurrent kidney biopsies
Original publication
Urinary CD163 is a marker of active kidney disease in childhood-onset lupus nephritis. Rheumatology (Oxford). Published 12 August 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →