Lupus & antiphospholipid syndrome
CD56brightCD16- to CD57+CD56dimCD16+ natural killer (NK) cell ratio discriminates disease activity and renal involvement in patients with systemic lupus erythematosus
Authors' conclusion
Our data indicate that the imbalance in Im NK and MD NK cells may play a role in lupus development and serve as a predictive biomarker to assess disease activity and renal involvement in patients with SLE.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE) and healthy controls; disease activity assessed by SLEDAI-2K
- Participants
- 68 vs 35
- Exposure
- SLE vs healthy controls; high-activity vs low-activity SLE
- SLEn = 68
- Healthy controlsn = 35reference
- Outcome
- Peripheral NK cells and subpopulations (Im NK-to-MD NK ratio) and their usability in monitoring disease activity
Methodological detailsflow cytometry
- Flow cytometry
Main finding
As reported in the abstract
Im NK-to-MD NK ratio
AUC of ratio for severe SLE
0.722
AUC of ratio for LN
0.773
Optimal cut-off for severe SLE
0.075
Optimal cut-off for LN
0.108
Observational data: associations, not effects.
Original publication
CD56brightCD16- to CD57+CD56dimCD16+ NK cell ratio discriminates disease activity and renal involvement in patients with systemic lupus erythematosus. Clin Exp Rheumatol. Published 12 August 2022. doi:10.
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