Lupus & antiphospholipid syndrome
Timing and Predictors of Incident Cardiovascular Disease in Systemic Lupus Erythematosus: Risk Occurs Early and Highlights Racial Disparities
Main finding · Incident CVDResult — go to the resultrisk 7-fold higherAuthors' conclusion
The frequency of incident CVD events peaked in years 2 and 11 after SLE diagnosis. Being Black or having a discoid rash were strong predictors of an incident CVD event.
Study context
- Population
- Incident systemic lupus erythematosus (SLE) cases from the population-based Georgia Lupus Registry (predominantly Black)253 (75%) Black
- Participants
- 336 cases
- Exposure
- Black vs non-Black people with SLE
- Blackn = 253
- Outcome
- Timing and predictors of incident CVD event
- Follow-up
- 15-year period
Methodological detailspopulation-based registry (Georgia Lupus Registry), 15-year surveillance period starting 2 years prior to SLE diagnosis
- Population-based registry (Georgia Lupus Registry)
- 15-year surveillance period starting 2 years prior to SLE diagnosis
Main finding
Incident CVD
risk
7-fold higher
P < 0.001
As reported in the abstract
- Incident cardiovascular disease (CVD) event
- 56 (17%)
- Discoid rash, HR for incident CVD
- 3.2 (95% CI 1.4-7.1)
Observational data: associations, not effects.
Original publication
Timing and Predictors of Incident Cardiovascular Disease in Systemic Lupus Erythematosus: Risk Occurs Early and Highlights Racial Disparities. J Rheumatol. Published 1 August 2022. doi:10.
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