Lupus & antiphospholipid syndrome
Deep remission within 12 months prevents renal flare and damage accrual in lupus nephritis
Authors' conclusion
Achievement of DR within 12 months after induction therapy should be a treatment target for active LN, as it has implications for preventing renal flare and damage accrual.
Study context
- Population
- Asian patients undergoing induction therapy for active lupus nephritis (LN)median observation 48.6 months
- Participants
- 59 patients
- Exposure
- Deep remission (DR) within 12 months vs no CR, DR after 12 months, and no DR but CR within 12 months
- DR within 12 monthsn = 33
- Outcome
- Renal flare and damage accrual rates
Methodological detailsconsecutive patients
- Consecutive patients
Main finding
As reported in the abstract
- DR within 12 months: significantly lower rate of subsequent renal flare than without CR, DR after 12 months, and no DR but CR within 12 months
- p<0.001
- DR within 12 months: significantly lower rate of damage accrual than the other groups
- p=0.046
Observational data: associations, not effects.
Further findings
Factors associated with DR within 12 months
- Younger age, shorter disease duration, lower baseline urine protein and earlier renal response associated with DR within 12 months
CR within 12 months
- Patients achieving CR
- 55
Original publication
Deep remission within 12 months prevents renal flare and damage accrual in lupus nephritis. Clin Exp Rheumatol. Published 29 July 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →