Lupus & antiphospholipid syndrome
Renal response status to predict long-term renal survival in patients with lupus nephritis: results from the Toronto Lupus Cohort
Authors' conclusion
Achieving mPERR or mCRR was associated with improved long-term renal survival
Study context
- Population
- Adults with SLE and biopsy-proven Class III±V, IV±V or V lupus nephritis (LN), University of Toronto Lupus Cohort, 1970–2015 (87.2% female; mean age 34.1 years)
- Participants
- 179 adults
- Exposure
- mPERR responders vs non-responders at 24 months postbiopsy
- mPERR respondersn = 128
- non-mPERR respondersn = 51reference
- mCRR respondersn = 102
- non-mCRR respondersn = 77reference
- Outcome
- Association of index mPERR status with long-term renal survival (no progression to end-stage kidney disease [eGFR <30 mL/min/1.73 m², dialysis or transplant] or death)
- Follow-up
- Up to 25 years
Methodological detailsobservational, GSK Study 212866
- Observational
- GSK Study 212866
Main finding
As reported in the abstract
Long-term renal survival by mPERR status
Log-rank p=0.0119
Observational data: associations, not effects.
Secondary outcomes
| Outcome | mCRR responders | non-mCRR responders | P value |
|---|---|---|---|
| Long-term renal survival by mCRR status · up to 25 yearsmCRR responders vs non-mCRR responders | 80.4% | 64.9% | log-rank p=0.0259 |
- Long-term renal survival by mCRR status: achieving mCRR associated with increased likelihood of long-term renal survival
Original publication
Renal response status to predict long-term renal survival in patients with lupus nephritis: results from the Toronto Lupus Cohort. Lupus Sci Med. Published 27 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →