Lupus & antiphospholipid syndrome
Altered structural and functional homotopic connectivity associated with cognitive changes in SLE
Authors' conclusion
The structural and functional changes of insula and parahippocampal gyrus might be potential neuroimaging markers, and specific antibodies associated with lupus might be involved in the pathophysiological mechanisms of brain dysfunction.
Study context
- Population
- Patients with SLE and age- and sex-matched healthy controls (HCs) undergoing MRI and neuropsychological testing
- Participants
- 54 vs 32
- Exposure
- SLE vs age- and sex-matched HCs
- SLEn = 54
- HCsn = 32reference
- Outcome
- VMHC values and grey matter volume between hemispheres
Methodological detailsage-matched and sex-matched healthy controls, voxel-mirrored homotopic connectivity (VMHC), correlation analysis
- Age-matched and sex-matched healthy controls
- Voxel-mirrored homotopic connectivity (VMHC)
- Correlation analysis
Main finding
As reported in the abstract
- SLE vs HCs: increased VMHC values in the insula and parahippocampal gyrus
- SLE vs HCs: reduced grey matter volume in the insula and parahippocampal gyrus
Observational data: associations, not effects.
Further findings
Correlations with cognition and lupus-specific antibodies in SLE
- Increased insula VMHC negatively correlated with decreased orientation function and positively correlated with decreased attention function
- Insula grey matter volume negatively correlated with decreased attention and abstraction
- VMHC values and grey matter volume in insula and parahippocampal gyrus negatively associated with lupus-specific antibodies
Original publication
Altered structural and functional homotopic connectivity associated with cognitive changes in SLE. Lupus Sci Med. Published 24 November 2024. doi:10.
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