Lupus & antiphospholipid syndrome
Long-term outcomes of lupus nephritis with low-level proteinuria: a multicentre, retrospective study
Authors' conclusion
Patients with LN and low-level proteinuria had favourable long-term renal and life outcomes.
Study context
- Population
- Japanese patients with biopsy-proven LN from 10 hospitals
- Participants
- 144 patients
- Exposure
- Low-level proteinuria vs high-level proteinuria
- Low-level proteinurian = 67
- Outcome
- ESRD and death
- Follow-up
- Total observation period (median, 72 months)
Methodological detailsmulticentre, 10 hospitals
- Multicentre
- 10 hospitals
Main finding
As reported in the abstract
ESRD
P = 0.036
Observational data: associations, not effects.
Further findings
Class III/IV LN frequency at renal biopsy
P = 0.409
- Death (co-outcome), incidence during total observation period · median, 72 months
- P = 0.006
Death (co-outcome), incidence during total observation period · median, 72 months
- Kaplan-Meier analysis showed significant differences in the incidence of death between the groups
- Multivariate Cox regression: significant risk factors for death were increased age and high-level proteinuria
Class III/IV LN frequency at renal biopsy
- Low-level proteinuria: significantly improved renal function at biopsy, low activity and chronicity index, less CYC usage
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Long-term outcomes of lupus nephritis with low-level proteinuria: a multicentre, retrospective study. Rheumatology (Oxford). Published 24 November 2023. doi:10.
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