Lupus & antiphospholipid syndrome
Predictors and prognostic stratification for lupus low disease activity state: results from a prospective clinical trial
Authors' conclusion
Renal involvement, haematological involvement and hypocomplementaemia were negative predictors of LLDAS achievement and maintenance. LLDAS-3mo was a positive predictor for the long-term sustainment of LLDAS.
Study context
- Population
- Active SLE patients, followed up quarterly from 2014 to 2016
- Participants
- 245 patients
- Exposure
- Low-risk vs intermediate-risk vs high-risk groups by prognostic stratification tool
- Low-riskn = 36
- Intermediate-riskn = 100
- High-riskn = 108
- Outcome
- Achievement of LLDAS
- Follow-up
- 2 years
Methodological detailsmultivariate analysis, prognostic stratification tool
- Multivariate analysis
- Prognostic stratification tool
Main finding
As reported in the abstract
Probability of achieving LLDAS
2-year probability of achieving lupus low disease activity state (LLDAS) (154/245)
62.9%
Observational data: associations, not effects.
Further findings
LLDAS-3mo as predictor for LLDAS-50
| Risk ratio (95% CI) | P value | ||
|---|---|---|---|
| LLDAS-3mo | 47.694 (13.776–165.127) | P < 0.0001 | |
| 0.050.21520Risk ratio (log scale) |
Achieving LLDAS by risk group
Achieving LLDAS-50 by risk group
Achieving LLDAS-3mo by risk group · 3 months
- Achieving LLDAS by risk group — Significant differences in LLDAS Kaplan-Meier estimates for the three risk groups
- P < 0.0001
Predictors for LLDAS-3mo (multivariate logistic analysis) · 3 months
- Negative predictors: aPL positivity, hypocomplementaemia, renal involvement and haematological involvement
Original publication
Predictors and prognostic stratification for lupus low disease activity state: results from a prospective clinical trial. Rheumatology (Oxford). Published 27 July 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →