Lupus & antiphospholipid syndrome
Thrombin generation test as a useful tool for improving disease severity stratification in antiphospholipid syndrome
Authors' conclusion
Our findings suggest that APS patients under VKA had significantly prolonged TGT times compared with anticoagulated controls, with the greatest prolongations in patients with history of relapse or CAPS.
Study context
- Population
- Primary thrombotic antiphospholipid syndrome (APS) patients treated by vitamin K antagonist (VKA), without SLE; single centre, January 2020–March 2023
- Participants
- 114 vs 28
- Exposure
- Thrombotic APS patients under VKA vs non-APS patients under VKA
- APSn = 114
- Controlsn = 28reference
- Outcome
- Thrombin generation test (calibrated automated thrombogram) parameters for APS disease severity stratification
Methodological detailsmonocentric, transversal
- Monocentric
- Transversal
Main finding
As reported in the abstract
Thrombin generation test (TGT) lag time (LT) and time to peak (TTP)
- APS patients had prolonged lag time (LT) and time to peak (TTP) vs anticoagulated controls
- History of relapse, catastrophic APS (CAPS), all aPL positivities and elevated Bb fragments strongly associated with prolonged LT and TTP
Observational data: associations, not effects.
Original publication
Thrombin generation test as a useful tool for improving disease severity stratification in antiphospholipid syndrome. RMD Open. Published 1 July 2025. doi:10.
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