Lupus & antiphospholipid syndrome
Comparative Analysis of Damage Accrual in Lupus Nephritis Stratified by Biological Sex
Authors' conclusion
Extrarenal and renal damage accrual are frequent in patients with LN and do not appear to be higher in male individuals.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE) from an observational cohort who developed lupus nephritis (LN) at or after clinic entry (83.5% female; median age 33 years)median follow-up 8.6 years
- Participants
- 460 patients
- Exposure
- Male vs female patients with LN
- Outcome
- Extrarenal damage (increase in nonrenal SLICC/ACR DI by ≥ 1) and renal damage (sustained ≥ 30% decline in eGFR or progression to end-stage kidney disease)
Methodological detailsobservational cohort, Fine-Gray subdistribution hazard models, Kaplan-Meier survival analysis, multivariable analysis
- Observational cohort
- Fine-Gray subdistribution hazard models
- Kaplan-Meier survival analysis
- Multivariable analysis
Main finding
As reported in the abstract
Damage accrual, male vs female (multivariable)
Male vs FemaleHazard ratio (95% CI)
Extrarenal damage
1.13(0.76–1.70)
Renal damage
1.26(0.67–2.36)
- Whole cohort: extrarenal damage accrued
- 45.3%
- Whole cohort: renal damage
- 32.2%
Observational data: associations, not effects.
Original publication
Comparative Analysis of Damage Accrual in Lupus Nephritis Stratified by Biological Sex. J Rheumatol. Published 1 July 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →