Lupus & antiphospholipid syndrome
Comparison of Lupus Nephritis Onset Before and After Age 50: Effect on Presentation and Outcomes in an Inception Cohort
Authors' conclusion
Late-onset LN is not associated with significant differences in short- or long-term renal outcomes.
Study context
- Population
- Inception cohort patients with systemic lupus erythematosus (SLE) who developed lupus nephritis (LN) during follow-up
- Participants
- 246 patients
- Exposure
- LN onset ≥ 50 years vs < 50 years
- Group 1n = 205reference
- Group 2n = 41
- Outcome
- CPR at 1 year and adverse composite outcome (end-stage renal disease, sustained ≥ 40% eGFR decline, or death)
Methodological detailsCox proportional hazards model
- Cox proportional hazards model
Main finding
As reported in the abstract
- No significant differences between the 2 groups in achieving complete proteinuria recovery (CPR) or developing the adverse composite outcome (Cox models)
Observational data: associations, not effects.
Further findings
Baseline median age
P < 0.01
- Baseline renal and disease activity measures
- P = 0.03
- Baseline renal and disease activity measures
- P < 0.01
- Baseline renal and disease activity measures
- P = 0.01
- Baseline renal and disease activity measures
- P = 0.04
Any increase in nonrenal SDI
- Late-onset LN associated with higher odds of any increase in nonrenal SDI
Subsequent LN flares
- Late-onset LN showed a trend for fewer subsequent flares
Original publication
Comparison of Lupus Nephritis Onset Before and After Age 50: Effect on Presentation and Outcomes in an Inception Cohort. J Rheumatol. Published 1 July 2025. doi:10.
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