Lupus & antiphospholipid syndrome
Lupus nephritis outcomes when kidney biopsy is not feasible: findings from a tertiary centre inception cohort
Authors' conclusion
Renal outcomes were not statistically different between biopsy-confirmed and clinically diagnosed LN when managed with standard treatment in a tertiary care setting.
Study context
- Population
- Patients with SLE enrolled 2000–2024 who developed incident lupus nephritis (LN) in an inception cohort at a tertiary centreincident LN
- Participants
- 127 patients
- Exposure
- Biopsy-confirmed LN vs clinically diagnosed LN
- Biopsy-confirmedn = 84reference
- Clinically diagnosedn = 43
- Outcome
- CPR at 6 months and one year; composite of sustained ≥30% eGFR decline, ESKD or death
Methodological detailsinception cohort, single tertiary centre, Kaplan-Meier curves and Cox proportional hazards regression
- Inception cohort
- Single tertiary centre
- Kaplan-Meier curves and Cox proportional hazards regression
Main finding
As reported in the abstract
CPR at 6 months and one year; composite outcome
Observational data: associations, not effects.
Further findings
Individual events: ≥30% eGFR decline, end-stage kidney disease (ESKD), death
- Not statistically different between groups
Baseline characteristics
- Clinically diagnosed patients were younger, with lower baseline proteinuria and disease activity
Original publication
Lupus nephritis outcomes when kidney biopsy is not feasible: findings from a tertiary centre inception cohort. Clin Exp Rheumatol. Published 15 December 2025. doi:10.
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