Lupus & antiphospholipid syndrome
Loss of antiphospholipid antibody positivity decreases the risk of recurrent thrombosis in thrombotic antiphospholipid syndrome
Main finding · Recurrent thrombosisResult — go to the resultHazard ratio 0.58 95% CI 0.29–1.14Authors' conclusion
The risk of recurrent thrombosis drops significantly after aPL-negativization
Study context
- Population
- Consecutive adults with thrombotic antiphospholipid syndrome (APS), all solid-phase aPL-positive at diagnosis, Hospital de Santa Maria, Lisbon, Portugal, up to December 20241,084 patient years
- Participants
- 116 adults
- Exposure
- aPL-negativization vs persistently aPL-positive
- Outcome
- Recurrent thrombosis under antithrombotic therapy
Methodological detailsconsecutive patients, single-centre, Cox regression
- Consecutive patients
- Single-centre
- Cox regression
Main finding
Recurrent thrombosis
Hazard ratio
0.58
95% CI 0.29–1.14
aPL-negativizationvs Persistently aPL-positive
HR 0.58 (95% CI 0.29–1.14)
As reported in the abstract
- Patients with recurrence
- 45 (38.8%); 68 recurrences (4.2 events/100PY)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Recurrent thrombosis among patients who became aPL-negative, before aPL-negativization | 0.52 (0.26–1.06) | ||
| Recurrent thrombosis among patients who became aPL-negative, after aPL-negativization | 0.12 (0.05–0.58) | P = 0.006 | |
| 0.050.21520Hazard ratio (log scale) |
- Recurrent thrombosis among patients who became aPL-negative, after aPL-negativization: dropped by 88%; adjusted for age, primary APS and type of initial thrombosis
aPL-negativization
- Became aPL-negative
- 31.9% (3.4 events/100PY)
- Triple aPL-positivity at diagnosis predicted against aPL-negativization; primary APS predicted aPL-negativization
Predictors of recurrence
- Age at APS onset, arterial thrombosis and persistent triple aPL-positivity predicted recurrence
Original publication
Loss of antiphospholipid antibody positivity decreases the risk of recurrent thrombosis in thrombotic antiphospholipid syndrome. Rheumatology (Oxford). Published 14 December 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →