Lupus & antiphospholipid syndrome
Predictors and long-term impact of sustained complete renal response in lupus nephritis patients over a median 10-year follow-up
Authors' conclusion
Persistent hydroxychloroquine, non-nephrotic baseline proteinuria and class III vs IV are associated with earlier sCRR. sCRR ≥4 years protects against ≥30% eGFR decline, composite ESKD/death and damage.
Study context
- Population
- Inception cohort patients with biopsy-proven lupus nephritis (LN) from two academic centresmedian 121-month follow-up
- Participants
- 142 patients
- Outcome
- Prevalence of sCRR achievement for ≥12 months
Methodological detailstwo academic centres, linear, logistic and Cox regression models
- Two academic centres
- Linear, logistic and Cox regression models
Main finding
As reported in the abstract
sCRR achievement
Sustained CRR (sCRR) for ≥12 months
83%
sCRR for ≥5 years
56.3%
sCRR for ≥10 years
20.4%
Observational data: associations, not effects.
Further findings
Predictors of earlier sCRR achievement
| aHR | P value | |
|---|---|---|
| Persistent HCQ use | 1.86 | P = 0.004 |
| Non-nephrotic baseline proteinuria | 1.71 | P = 0.016 |
| Outcome | Estimate | P value |
|---|---|---|
| Predictors of earlier sCRR achievementClass III LN vs Class IV LN | HR 1.89 | P = 0.018 |
| Long-term outcomes by sCRR duration (per year)sCRR duration (per year) · ≥30% eGFR decline · sCRR duration rather than its mere achievement | aOR 0.81 per year | P = 0.015 |
| Long-term outcomes by sCRR duration (per year)sCRR duration (per year) · composite ESKD/death · sCRR duration rather than its mere achievement | aHR 0.75 per year | P = 0.001 |
| Damage accrual with sCRR ≥ 12 months | adjusted β-coef −1.17 | P < 0.001 |
| Outcomes with sCRR ≥ 4 years (subgroup with ≥100-month follow-up)sCRR ≥ 4 years · severe kidney function decline | aOR 0.10 | P = 0.005 |
| Outcomes with sCRR ≥ 4 years (subgroup with ≥100-month follow-up)sCRR ≥ 4 years · ESKD/death | aHR 0.11 | P = 0.043 |
| Outcomes with sCRR ≥ 4 years (subgroup with ≥100-month follow-up)sCRR ≥ 4 years · damage accrual | adjusted β-coef −0.81 | P = 0.012 |
Renal flares after sCRR · 5 and 10 years post-sCRR
- Risks for renal flares decreased for every additional year on complete renal response (CRR)
Original publication
Predictors and long-term impact of sustained complete renal response in lupus nephritis patients over a median 10-year follow-up. Rheumatology (Oxford). Published 13 December 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →