Lupus & antiphospholipid syndrome
Beyond renal response: sustained systemic disease control protects against adverse long-term outcomes in lupus nephritis
Authors' conclusion
Following renal response, achievement of mLLDAS and mDORIS is strongly associated with improved outcomes in LN patients. Earlier attainment and longer duration in these states confer progressively greater protection.
Study context
- Population
- Patients with biopsy-proven lupus nephritis (LN) who achieved renal response; enrolment at first renal response
- Participants
- 127 vs 92
- Exposure
- Attainment of mLLDAS or mDORIS vs non-attainment, after renal response
- mLLDASn = 127
- mDORISn = 92
- Outcome
- Organ damage accrual, renal flares and CKD
Methodological detailsmulticentre, Cox proportional hazards models
- Multicentre
- Cox proportional hazards models
Main finding
As reported in the abstract
Organ damage · median follow-up 3.5 years (IQR 4.5)
Adjusted hazard ratio (95% CI)
mLLDAS85% risk reduction
0.15(0.07–0.32)
mDORIS79% reduction
0.21(0.08–0.55)
Observational data: associations, not effects.
Further findings
Renal flare
| aHR (95% CI) | ||
|---|---|---|
| mLLDAS73% reduction | 0.27 (0.14–0.51) | |
| 0.10.31310Adjusted hazard ratio (log scale) |
Early attainment: damage accrual
| aHR (95% CI) | ||
|---|---|---|
| Early attainment | 0.31 (0.16–0.61) | |
| 0.10.31310Adjusted hazard ratio (log scale) |
Early attainment: renal flares
| aHR (95% CI) | ||
|---|---|---|
| Early attainment | 0.51 (0.29–1.00) | |
| 0.20.5125Adjusted hazard ratio (log scale) |
Renal flare
- Similar effects for mDORIS
Sustained achievement
- Progressively greater protection, strongest for ≥24 consecutive months
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Beyond renal response: sustained systemic disease control protects against adverse long-term outcomes in lupus nephritis. Lupus Sci Med. Published 27 May 2026. doi:10.
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