Lupus & antiphospholipid syndrome
Pancarditis and fibrosis as hallmarks of lupus myocarditis: clinical features, imaging findings and outcomes
Authors' conclusion
LM is a distinct and severe phenotype of SLE, characterized by pancarditis and unique imaging features.
Study context
- Population
- Lupus myocarditis (LM) patients diagnosed 2005–2022, matched with active systemic lupus erythematosus (SLE)-non-LM and AM-non-AI32 LM patients
- Exposure
- LM vs active SLE without myocarditis vs acute non-autoimmune myocarditis
- LMn = 32
- Outcome
- Wall motion abnormalities on echocardiography
Methodological detailsmatched 1:1 by age and sex, 2-year follow-up
- Matched 1:1 by age and sex
- 2-year follow-up
Main finding
As reported in the abstract
P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | LM | AM-non-AI | P value |
|---|---|---|---|
| Reduced LV ejection fractionLM vs AM-non-AI | 56.3% | 18.8% | P = 0.002 |
| Pulmonary hypertensionLM vs AM-non-AI | 37.5% | 3.1% | P = 0.001 |
| Valvular abnormalitiesLM vs AM-non-AI | 65.5% | 3.1% | P < 0.001 |
| Late gadolinium enhancement on CMRLM vs AM-non-AI · comparator group not named for this result in the abstract | 65.6% | 37.5% | P = 0.024 |
| PancarditisLM vs AM-non-AI | 65.6% | 0% | P < 0.001 |
| ICU admissionLM vs AM-non-AI | 28.1% | 6.3% | P = 0.043 |
| Invasive mechanical ventilationLM vs AM-non-AI | 25.0% | 3.1% | P = 0.027 |
- Pancarditis: identified exclusively in LM; comparator not named in the abstract
Mortality · 2 years
- Comparable between LM and AM-non-AI
Original publication
Pancarditis and fibrosis as hallmarks of lupus myocarditis: clinical features, imaging findings and outcomes. Rheumatology (Oxford). Published 3 February 2026. doi:10.
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