Lupus & antiphospholipid syndrome
Colchicine usage and recurrent pericarditis in patients with systemic lupus erythematosus
Authors' conclusion
In this study, recurrent pericarditis was common among patients with SLE and was associated with treatment with glucocorticoids. Colchicine was associated with a trend toward decreased recurrence rates, but this was not statistically significant. Given high recurrence rates among patients treated with steroids, additional studies are needed on non-steroidal therapies for pericarditis in SLE, including further research on colchicine.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE) treated at a tertiary care center between 2015 and 2025 who presented to the hospital with pericarditis based on the 2025 European Society of Cardiology (ESC) Guidelines and had follow-up for at least 1 yearpatients included in the study
- Participants
- 55 patients
- Outcome
- Recurrent pericarditis
- Follow-up
- Within 1 year of the initial presentation
Methodological detailsmultivariate logistic regression
- Multivariate logistic regression
Main finding
As reported in the abstract
Recurrent pericarditis occurred in
45.5% of patients
Observational data: associations, not effects.
Further findings
Recurrent pericarditis, treatment with glucocorticoids (multivariate logistic regression)
| Odds ratio (95% CI) | ||
|---|---|---|
| Treatment with glucocorticoids | 4.31 (1.12–16.55) | |
| 0.050.21520Odds ratio (log scale) |
- Recurrent pericarditis, treatment with glucocorticoids (multivariate logistic regression): multivariate logistic regression including age, treatment with colchicine, and treatment with glucocorticoids; only treatment with glucocorticoids was significantly associated
Factors associated with recurrent pericarditis (univariate analyses)
- Age less than 40 years at first presentation of pericarditis significantly associated with recurrent pericarditis
- Treatment with an initiation or increase of glucocorticoids significantly associated with recurrent pericarditis
- Treatment with colchicine trended toward reduced recurrence, not statistically significant
Treatments received
- Received colchicine
- 47.3%
- Received non-steroidal anti-inflammatory drugs (NSAIDs)
- 52.7%
- Received glucocorticoids
- 56.4%
Original publication
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