Lupus & antiphospholipid syndrome
Systemic Immune-Inflammation Index (SII) correlates with disease activity but not with interferon-associated chemokines in SLE
Authors' conclusion
Although the SII correlates with overall SLE disease activity, it does not reflect circulating concentrations of interferon-associated chemokines.
Study context
- Population
- Women with SLE and healthy female controls95 women with SLE and 1443 healthy female controls
- Participants
- 95 vs 1,443
- Exposure
- Patients with SLE vs healthy controls
- SLEn = 95
- HEALTHY CONTROLSn = 1,443
- Outcome
- Median SII
Methodological detailstwo established cohorts
- Two established cohorts
Main finding
As reported in the abstract
SLE
588.8
median · IQR 390.8–964.8
HEALTHY CONTROLS
521.4
median · IQR 381.6–690.5
Observational data: associations, not effects.
Further findings
Discriminatory performance of SII, SLE vs healthy controls
- AUC
- 0.57; 95% CI 0.49 to 0.64; p=0.022
Correlation of SII with SLEDAI-2K scores (SLE cohort)
- Spearman’s ρ
- 0.303; 95% CI 0.102 to 0.480; p=0.003
Correlation of SII with circulating chemokines (SLE cohort)
- No significant correlations with any circulating chemokines
Correlation of SLEDAI-2K with serum CCL5/RANTES
- ρ
- 0.257; 95% CI 0.008 to 0.475; unadjusted p=0.037
- No chemokine maintained statistical significance after false discovery rate multiple-testing correction
Correlation of SLEDAI-2K with CXCL8
- ρ
- 0.228; 95% CI 0.012 to 0.422; unadjusted p=0.032
- No chemokine maintained statistical significance after false discovery rate multiple-testing correction
Original publication
Systemic Immune-Inflammation Index (SII) correlates with disease activity but not with interferon-associated chemokines in SLE. Lupus Sci Med. Published 22 October 2026. doi:10.
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