Lupus & antiphospholipid syndrome
Topical Mupirocin Treatment Reduces Interferon and Myeloid Signatures in Cutaneous Lupus Erythematous Lesions Through Targeting of Staphylococcus Species
Authors' conclusion
Mupirocin treatment decreased lesional Staphylococcus, and this correlated with decreased IFN signaling and inflammatory gene expression.
Study context
- Population
- Participants with active cutaneous lupus erythematosus (CLE) lesions
- Participants
- 12 participants
- Comparison
- Topical 2% mupirocin vs petroleum jelly vehicle for one week
Methodological detailsproof-of-concept, vehicle-controlled
- Proof-of-concept
- Vehicle-controlled
Primary result
As reported in the abstract
Lesional gene expression after mupirocin · 7 days
- Differentially expressed genes in CLE lesions after topical mupirocin
- 173
Original publication
Topical Mupirocin Treatment Reduces Interferon and Myeloid Signatures in Cutaneous Lupus Erythematous Lesions Through Targeting of Staphylococcus Species. Arthritis Rheumatol. Published 23 January 2025. doi:10.
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