Lupus & antiphospholipid syndrome
Interferon-gamma (IFN-γ) intronic variant (rs2430561) is a risk factor for systemic lupus erythematosus: Observation from a meta-analysis
Authors' conclusion
IFN-γ +874 T>A variant is associated with predisposition to SLE development.
Study context
- Population
- Case-control studies of IFN-γ +874 T>A polymorphism in systemic lupus erythematosus (SLE) (rheumatoid arthritis (RA) studies excluded for Hardy-Weinberg deviation)5 studies
- Participants
- 1,440 vs 1,748
- Comparison
- IFN-γ +874 T>A variants vs wild type in SLE patients vs controls
- SLEn = 1,440
- Controlsn = 1,748reference
- Outcome
- Association of IFN-γ +874 T>A variants with susceptibility to SLE
Methodological detailstrial sequential analysis
- Trial sequential analysis
Pooled result
As reported in the abstract
Susceptibility to SLE
Odds ratio
1.592
P = 0.036
homozygous comparison
Odds ratio
1.507
P = 0.042
heterozygous model
Odds ratio
1.309
P = 0.002
dominant model
Original publication
Interferon-gamma (IFN-γ) intronic variant (rs2430561) is a risk factor for systemic lupus erythematosus: Observation from a meta-analysis. Lupus. Published 20 December 2022. doi:10.
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