Lupus & antiphospholipid syndrome
Evaluating the Construct of Damage in Systemic Lupus Erythematosus
Authors' conclusion
We identified shifts in the paradigm of SLE damage and developed a unifying conceptual framework.
Study context
- Population
- International systemic lupus erythematosus (SLE) experts
- Participants
- 50 experts13 countries
- Outcome
- Construct of SLE damage for the revised SDI
Methodological details3-part, facilitated small groups, consensus meeting using nominal group technique, international SLE experts
- 3-part
- Facilitated small groups
- Consensus meeting using nominal group technique
- International SLE experts
Recommendations
As reported in the abstract
- 8 thematic clusters: purpose, items, weighting, reversibility, impact, time frame, attribution and perspective
- Revised SDI: discriminative index measuring morbidity in SLE, independent of activity or impact on the patient, and should be related to mortality
- SDI primarily intended for research, with a life-course approach
- Damage can occur before SLE diagnosis but should be attributable to SLE
- Organ damage is irreversible, but its functional consequences may improve through physiological adaptation or treatment
Original publication
Evaluating the Construct of Damage in Systemic Lupus Erythematosus. Arthritis Care Res (Hoboken). Published 20 December 2022. doi:10.
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