Lupus & antiphospholipid syndrome
Serological markers of basement membrane collagen type IV and laminin are increased in systemic lupus erythematosus but differentially expressed in patients with previous cardiovascular events
Authors' conclusion
These findings indicate that remodelling of collagen type IV and laminin is increased in SLE unrelated to disease activity, presumably reflecting clinically silent disease progression.
Study context
- Population
- Systemic lupus erythematosus (SLE) patients with and without previous cardiovascular events and blood donor controls
- Exposure
- SLE vs blood donor controls; SLE with vs without previous CV events
- SLE without previous cardiovascular events (CVE)n = 106
- SLE with previous CVEn = 20
- Controlsn = 120reference
- Outcome
- Serum levels of type IV collagen (C4M) and laminin (LG1M) fragments
Main finding
As reported in the abstract
| Group | Value | C4M median (IQR) |
|---|---|---|
| SLE | median 15.8 (IQR 26.16) ng/ml | 31.3 (20.0) |
| Controls | median 5.5 (IQR 5.8) ng/ml | 21.6 (9.2) ng/ml |
Value
SLEmedian 15.8 (IQR 26.16) ng/ml
Controlsmedian 5.5 (IQR 5.8) ng/ml
C4M median (IQR)
SLE31.3 (20.0)
Controls21.6 (9.2) ng/ml
- SLE vs Controls: P < 0.0001 — LG1M
- SLE vs Controls: P < 0.0001 — C4M
Observational data: associations, not effects.
Further findings
| Outcome | SLE without previous CVE | SLE with previous CVE | P value |
|---|---|---|---|
| LG1M, SLE with vs without previous CVE | 14.1 | 27.2 | P < 0.03 |
- LG1M in aPL-positive vs negative patients · borderline higher; not C4M
- P = 0.08
- LG1M, SLE with vs without previous CVE: spread printed: 30.8 vs 21.4
LG1M, SLE with vs without previous CVE
- C4M did not differ between these subsets
Correlation C4M with LG1M
- R in patients (p<0.0001)
- 0.44
- R in controls (p<0.0001)
- 0.42
LG1M correlation with SLICC-DI
- Weak correlation, r (p=0.01)
- 0.22
- No associations with criterial lupus manifestations or asymptomatic atherosclerosis
Original publication
Serological markers of basement membrane collagen type IV and laminin are increased in systemic lupus erythematosus but differentially expressed in patients with previous cardiovascular events. Clin Exp Rheumatol. Published 16 December 2022. doi:10.
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