Lupus & antiphospholipid syndrome
Vascular events in autoantibody-defined clusters of SLE: a 12-year prospective cohort study
Authors' conclusion
We observed differences regarding the incidence of MACE and VTE during 12 years of follow-up for four autoantibody-defined clusters. The highest incidences were seen in the aPL-dominated cluster, while the lowest were detected in the autoantibody-negative cluster.
Study context
- Population
- SLE patients stratified by four autoantibody-defined clusters, without previous vascular events, and matched population controlsmean follow-up 12.2 ± 5.6 years
- Participants
- 461 patients
- Exposure
- Autoantibody-defined SLE clusters compared with each other and with matched controls
- Cluster 2n = 105
- Cluster 3n = 154
- Cluster 4n = 61
- Outcome
- Incident major cardiovascular events (MACE) and VTE
Methodological detailsmatched controls (1:10 on birth/sex/residence), Cox proportional hazards models, age-adjusted
- Matched controls (1:10 on birth/sex/residence)
- Cox proportional hazards models
- Age-adjusted
Main finding
As reported in the abstract
Cluster 3 vs Reference clustersHazard ratio (95% CI)
MACE; age-adjusted
1.91(1.01–3.58)
VTE; age-adjusted
2.69(1.05–6.9)
Observational data: associations, not effects.
Original publication
Vascular events in autoantibody-defined clusters of SLE: a 12-year prospective cohort study. Rheumatology (Oxford). Published 12 February 2026. doi:10.
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