Lupus & antiphospholipid syndrome

The impact of a peer-mentoring intervention on self-reported flare and disease activity among African American women with Systemic Lupus Erythematosus (SLE)

LupusPublished Secondary analysis of the PALS randomised controlled trial

Study context

Population
Adult African American women with SLE
Comparison
Peer-mentoring intervention vs social support control; peer mentors also assessed
Primary endpoint
Self-reported disease activity, symptom severity and flare frequency (Systemic Lupus Activity Questionnaire (SLAQ))
Follow-up
Baseline, 3, 6 and 12 months after the intervention
Methodological detailssub-analysis, linear and cumulative logit mixed models, adjusted for sociodemographic covariates
  • Sub-analysis
  • Linear and cumulative logit mixed models
  • Adjusted for sociodemographic covariates

Primary result

As reported in the abstract

Symptom severity (SLAQ), Intervention
  • Intervention reported sustained reductions in symptom severity over time, not statistically significant

Further findings

OutcomeMean difference (95% CI)
Symptom severity (SLAQ), Mentors · 3 monthsMentorsvs Social support controlSignificant improvement−2.53 (−4.95 to −0.11)

Employment and insurance status

Employment and insurance status consistently associated with lower symptom burden and disease activity

Original publication

The impact of a peer-mentoring intervention on self-reported flare and disease activity among African American women with Systemic Lupus Erythematosus (SLE). Lupus. Published 11 February 2026. doi:10.1177/09612033261422819

Composed by AI from the published abstract and checked against it. How Briefs are made →

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