Lupus & antiphospholipid syndrome
Phenotypic clustering of cardiovascular risk profiles in systemic lupus erythematosus
Authors' conclusion
SLE cardiovascular risk profiles encompass three subgroups with distinct cardiometabolic phenotypes and risk of incident cardiovascular events.
Study context
- Population
- Consecutive systemic lupus erythematosus (SLE) patients with a comprehensive cardiovascular risk assessment at the French National Referral Center for SLE, 2014–2024 (91% females, 45 ± 13 years)91% females
- Participants
- 226 patients
- Exposure
- Three cardiovascular risk phenotype clusters compared with each other
- Cluster 1n = 123
- Cluster 2n = 78
- Cluster 3n = 25
- Outcome
- Distinct cardiovascular risk phenotypes (clusters); incident atherosclerotic cardiovascular disease (ASCVD) event rates, follow-up CAC scores and annualized CAC progression rates compared across clusters
Methodological detailsunsupervised hierarchical cluster analysis, post-clustering decision tree
- Unsupervised hierarchical cluster analysis
- Post-clustering decision tree
Main finding
As reported in the abstract
Incident ASCVD event rates, follow-up CAC scores and annualized CAC progression rates
- Significantly differed between the three clusters (C3>C2>C1)
- all P < .01
Observational data: associations, not effects.
Further findings
Key determinants of cluster membership (post-clustering decision tree)
- Age, diabetes mellitus and epicardial adipose tissue volume
Original publication
Phenotypic clustering of cardiovascular risk profiles in systemic lupus erythematosus. Lupus. Published 11 February 2026. doi:10.
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