Lupus & antiphospholipid syndrome
Identifying high-risk profile in primary antiphospholipid syndrome through cluster analysis: French multicentric cohort study
Authors' conclusion
We identified four clusters among patients with primary APS, one of which was 'high-risk APS'.
Study context
- Population
- Patients with persistent aPL (Sydney criteria) measured January 2012–January 2019, French multicentre cohort; SLE or other systemic autoimmune diseases excluded
- Exposure
- Four clusters identified among patients with primary antiphospholipid syndrome (APS) and asymptomatic aPL carriers
- Outcome
- Clusters identified
Methodological detailsmulticentre, hierarchical cluster analysis on factor analysis of mixed data
- Multicentre
- Hierarchical cluster analysis on factor analysis of mixed data
Main finding
As reported in the abstract
- Four clusters identified: asymptomatic aPL carriers, male thrombotic phenotype, female obstetrical phenotype, high-risk APS
Observational data: associations, not effects.
Further findings
Relapse and death during follow-up (survival analyses)
- Asymptomatic aPL carriers relapsed less frequently than the others
- No other differences in relapse rates or deaths between clusters
Original publication
Identifying high-risk profile in primary antiphospholipid syndrome through cluster analysis: French multicentric cohort study. RMD Open. Published 9 March 2023. doi:10.
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