Lupus & antiphospholipid syndrome
Risk of COVID-19 among unvaccinated and vaccinated patients with systemic lupus erythematosus: a general population study
Main finding · SARS-CoV-2 infection, unvaccinated cohort (rate per 1000 person-months)Result — go to the resultAdjusted hazard ratio 1.28 95% CI 1.03–1.59Authors' conclusion
While unvaccinated patients with SLE were at higher risk of SARS-CoV-2 infection and its severe sequelae than the general population, no such difference was observed among vaccinated population.
Study context
- Population
- Individuals aged 18–90 years with no previously documented SARS-CoV-2 infection, The Health Improvement Networkunvaccinated cohort: 3245 systemic lupus erythematosus (SLE), 1,755,034 non-SLE
- Exposure
- SLE vs general population, by COVID-19 vaccination status
- Outcome
- SARS-CoV-2 infection and severe sequelae (COVID-19 hospitalisation, COVID-19 death, combined severe outcomes)
Methodological detailsgeneral population study, exposure score overlap weighted Cox proportional hazards model
- General population study
- Exposure score overlap weighted Cox proportional hazards model
Main finding
As reported in the abstract
SARS-CoV-2 infection, unvaccinated cohort (rate per 1000 person-months)
Adjusted hazard ratio
1.28
95% CI 1.03–1.59
By group
SLEvs General population
aHR 1.28 (95% CI 1.03–1.59)
Observational data: associations, not effects.
Further findings
Per 1000 person-months
| Outcome | SLE | General population | aHR (95% CI) | |
|---|---|---|---|---|
| COVID-19 hospitalisation, unvaccinated cohort (rate per 1000 person-months) | 3.21 | 1.77 | 1.82 (1.21–2.74) | |
| COVID-19 death, unvaccinated cohort (rate per 1000 person-months) | 1.16 | 0.53 | 2.16 (1.00–4.79) | |
| Combined severe outcomes, unvaccinated cohort (rate per 1000 person-months) | 3.86 | 2.18 | 1.78 (1.21–2.61) | |
| 0.20.5125Adjusted hazard ratio (log scale) |
Infection and severe sequelae, vaccinated cohort · 9 months of follow-up
- No statistically significant differences between vaccinated SLE and vaccinated general population
Original publication
Risk of COVID-19 among unvaccinated and vaccinated patients with systemic lupus erythematosus: a general population study. RMD Open. Published 8 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →