Lupus & antiphospholipid syndrome
Association of Vaccination With COVID Outcomes in Pregnant People With Autoimmune Diseases: A Retrospective National Cohort Analysis
Main finding · Time to COVID-19 in AIRDs, initial vaccination (pre-Omicron period)Result — go to the resultAdjusted TR 1.095 95% CI 1.036–1.157Authors' conclusion
Vaccination is associated with protection against COVID-19 in pregnancy, but its effectiveness is reduced in those with AIRDs, particularly during the Omicron period.
Study context
- Population
- Pregnant individuals aged 15 to 55 years with pregnancies between December 10, 2020, and June 1, 2024; national electronic health records4,715 (1.5%) with AIRD
- Participants
- 270,811 individuals
- Exposure
- COVID-19 vaccination (initial or booster) vs no vaccination in pregnant individuals with autoimmune rheumatic diseases (AIRDs); AIRDs vs no AIRDs among vaccinated
- AIRDsn = 4,715
- Outcome
- Time to incident and severe COVID-19
Methodological detailsnational electronic health records, adjusted time ratios, stratified by variant period (pre-Omicron vs Omicron)
- National electronic health records
- Adjusted time ratios
- Stratified by variant period (pre-Omicron vs Omicron)
Main finding
As reported in the abstract
Time to COVID-19 in AIRDs, initial vaccination (pre-Omicron period)
Adjusted TR
1.095
95% CI 1.036–1.157
Observational data: associations, not effects.
Further findings
| Outcome | Adjusted TR (95% CI) |
|---|---|
| Time to COVID-19 in AIRDs, initial vaccination (Omicron period)vs unvaccinated | 1.039 (0.980–1.102) |
| Infection in AIRDs, booster vaccinationNot significantly protective | 1.039 (0.958–1.128) |
| Severe COVID-19 in AIRDs, booster vaccinationNot significantly protective | 1.119 (0.670–1.867) |
| Time to breakthrough infection, vaccinated with vs without AIRDsWith AIRDs vs without AIRDs · pre-Omicron period | 0.940 (0.891–0.991) |
| Time to breakthrough infection, vaccinated with vs without AIRDsWith AIRDs vs without AIRDs · Omicron period | 0.905 (0.858–0.955) |
| Time to severe disease, vaccinated with vs without AIRDs (Omicron period) | 0.631 (0.485–0.821) |
Original publication
Association of Vaccination With COVID Outcomes in Pregnant People With Autoimmune Diseases: A Retrospective National Cohort Analysis. Arthritis Care Res (Hoboken). Published 18 May 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →