Lupus & antiphospholipid syndrome
Voclosporin and Changes in Blood Pressure: An Analysis of Real‐World Data
Authors' conclusion
Our results may differ because of differences in the intensity of BP management or the higher prevalence of cardiovascular risk factors in US patients.
Study context
- Population
- Patients with lupus nephritis (LN) starting voclosporin, US practices (mean age 41.4 years; 83.6% women); mean baseline blood pressure (BP) 126/79 (SD 16/11) mm Hg
- Participants
- 287 patients
- Exposure
- BP changes after starting voclosporin, by baseline BP
- Outcome
- Time from first voclosporin prescription to MCID increase in systolic (10 mm Hg) or diastolic (5 mm Hg) BP; mean change in BP from baseline
- Follow-up
- 0 to 1, 1 to 2, 2 to 3, 3 to 6, 6 to 9, and 9 to 12 months
Methodological detailsreal-world data, EHR data from US practices, stratified by baseline BP
- Real-world data
- EHR data from US practices
- Stratified by baseline BP
Main finding
As reported in the abstract
Systolic BP MCID
| Group | Value | Median time to systolic MCID |
|---|---|---|
| Overall | 60.3% | 90 days (95% CI 70-102) |
Overall
Value60.3%
Median time to systolic MCID90 days (95% CI 70-102)
Observational data: associations, not effects.
Further findings
| Outcome | Normal | Elevated | High |
|---|---|---|---|
| Mean systolic BP change, by baseline BP · first month | mean 13.7 ± 18.6 mm Hg | mean 2.7 ± 18.8 mm Hg | mean 7.9 ± 17.8 mm Hg |
| Mean diastolic BP change, by baseline BP · first month | mean 6.0 ± 13.8 mm Hg | mean −0.6 ± 11.2 mm Hg | mean −7.3 ± 16.5 mm Hg |
- Diastolic BP MCID: Overall 60.6% · median time to diastolic MCID 88 days (95% CI 72-111)
Original publication
Voclosporin and Changes in Blood Pressure: An Analysis of Real‐World Data. Arthritis Care Res (Hoboken). Published 18 May 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →