Lupus & antiphospholipid syndrome
Reversibility of pulmonary hypertension in systemic lupus erythematosus after induction immunosuppressive therapy: An inflammatory manifestation?
Authors' conclusion
This is the first study that identified that more than one third of SLE-PAH had a complete reversion of PAH after IS therapy with a significant impact on their survival.
Study context
- Population
- SLE-PAH patients who underwent induction immunosuppressive therapy at a single centreof 2,074 SLE patients
- Participants
- 28 patients
- Exposure
- Reversion vs No-Reversion of SLE-PAH after induction immunosuppressive therapy
- Reversionn = 10
- Outcome
- PAH reversion to a normopressoric state after induction immunosuppressive therapy
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
SLE-PAH reversion
Reversion
35.7%
10
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Baseline predictors of reversionReversion vs No-Reversion · lower sPAP | P = 0.032 |
| Baseline predictors of reversionReversion vs No-Reversion · lower right ventricle dilatation frequency | P = 0.003 |
| Baseline predictors of reversionReversion vs No-Reversion · lower hypokinesia frequency | P = 0.017 |
| Baseline predictors of reversionReversion vs No-Reversion · lower BNP levels | P = 0.041 |
| Baseline predictors of reversionReversion vs No-Reversion · lower risk stratification score | P = 0.014 |
| Risk stratification score and survival after ISBetter survival rate in Reversion | P = 0.047 |
Baseline predictors of reversion
- Demographics, disease duration, SLEDAI-2K and SDI similar between groups (p > 0.05)
- Hemodynamic parameters similar among groups (p > 0.05)
CRP and SLEDAI-2K after immunosuppressive (IS)
- Significant decrease in CRP only in Reversion (p = 0.013)
- Significant reduction in SLEDAI-2K in both groups (p < 0.05)
Risk stratification score and survival after IS
- Significant improvement in risk stratification score in both groups (p = 0.009 and p < 0.001)
Original publication
Reversibility of pulmonary hypertension in systemic lupus erythematosus after induction immunosuppressive therapy: An inflammatory manifestation? Lupus. Published 15 November 2024. doi:10.
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