Lupus & antiphospholipid syndrome
Clinical, serological and haemodynamic factors associated with poor outcomes in systemic lupus erythematosus-associated pulmonary arterial hypertension: a multicentre retrospective study from Korea
Authors' conclusion
Elevated mPAP, active lupus and use of combination PAH therapy were independently associated with poor outcomes in SLE-PAH
Study context
- Population
- Korean patients with SLE-associated PAH confirmed by right heart catheterization, eight tertiary centres
- Participants
- 68 patients
- Exposure
- Patients with vs without composite outcomes
- Composite outcomesn = 35
- Outcome
- Composite of:
- Worsening PAH symptoms requiring treatment escalation
- Lung transplantation
- Death
- Hospitalization
Methodological detailsmulticentre, univariable and multivariable logistic regression
- Multicentre
- Univariable and multivariable logistic regression
Main finding
As reported in the abstract
Composite outcome
Composite outcomes
51.3%
35
- Independent predictor (multivariable): elevated mean pulmonary arterial pressure (mPAP), OR 5.401 (95% CI 1.129-25.837)
- P = 0.035
- Independent predictor (multivariable): higher SLE Disease Activity Index (SLEDAI), OR 5.495 (95% CI 1.041-29.012)
- P = 0.045
- Independent predictor (multivariable): combination PAH therapy, OR 1.695 (95% CI 1.015-3.267)
- P = 0.017
Observational data: associations, not effects.
Further findings
Univariable differences, composite outcomes vs without
- Shorter baseline 6-min walk distance
- P = 0.024
- Higher tricuspid regurgitation velocity
- P = 0.032
- Higher right ventricular systolic pressure
- P = 0.035
- Higher mPAP
- P < 0.001
- Higher mean PGA scores
- P = 0.001
- Higher mean SLEDAI scores
- P = 0.005
- More frequent combination PAH therapy
- P = 0.033
Original publication
Clinical, serological and haemodynamic factors associated with poor outcomes in systemic lupus erythematosus-associated pulmonary arterial hypertension: a multicentre retrospective study from Korea. Rheumatology (Oxford). Published 30 March 2026. doi:10.
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